Some practitioners believe that Hashimoto’s disease, which can be confirmed by testing for thyroid antibodies , warrants treatment in some patients who are symptomatic, even if other thyroid levels are normal. There is also some evidence that treating Hashimoto’s disease with thyroid hormone replacement drugs before the thyroid stimulating hormone (TSH) level rises may alleviate some symptoms. Some research also suggests that treating someone with Hashimoto’s who otherwise has normal blood tests, including a normal TSH level, may help prevent elevation of the TSH level and progression to full hypothyroidism. Treating Hashimoto's when the TSH is normal is controversial, however.
Corticosteroid myopathy presents as weakness and wasting of the proximal limb and girdle muscles and is generally reversible following cessation of therapy.
Corticosteroids inhibit intestinal calcium absorption and increase urinary calcium excretion leading to bone resorption and bone loss. Bone loss of 3% over one year has been demonstrated with prednisolone 10 mg per day. Postmenopausal females are particularly at risk for loss of bone density. Sixteen percent of elderly patients treated with corticosteroids for 5 years may experience vertebral compression fractures. One author reported measurable bone loss over two years in women on concomitant therapy with prednisolone mg per day and tamoxifen. [ Ref ]