Mycology is a relatively new science that became systematic after the development of the microscope in the 17th century. Although fungal spores were first observed by Giambattista della Porta in 1588, the seminal work in the development of mycology is considered to be the publication of Pier Antonio Micheli 's 1729 work Nova plantarum genera .  Micheli not only observed spores but also showed that, under the proper conditions, they could be induced into growing into the same species of fungi from which they originated.  Extending the use of the binomial system of nomenclature introduced by Carl Linnaeus in his Species plantarum (1753), the Dutch Christian Hendrik Persoon (1761–1836) established the first classification of mushrooms with such skill so as to be considered a founder of modern mycology. Later, Elias Magnus Fries (1794–1878) further elaborated the classification of fungi, using spore color and various microscopic characteristics, methods still used by taxonomists today. Other notable early contributors to mycology in the 17th–19th and early 20th centuries include Miles Joseph Berkeley , August Carl Joseph Corda , Anton de Bary , the brothers Louis René and Charles Tulasne , Arthur H. R. Buller , Curtis G. Lloyd , and Pier Andrea Saccardo . The 20th century has seen a modernization of mycology that has come from advances in biochemistry , genetics , molecular biology , and biotechnology . The use of DNA sequencing technologies and phylogenetic analysis has provided new insights into fungal relationships and biodiversity , and has challenged traditional morphology-based groupings in fungal taxonomy . 
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