Aspiration pneumonia in adults
Bacterial pulmonary infections in HIV-infected patients
Clinical manifestations and diagnosis of Legionella infection
Clinical presentation and diagnosis of Pneumocystis pulmonary infection in HIV-infected patients
Clinical presentation and diagnostic evaluation of ventilator-associated pneumonia
Community-acquired pneumonia in adults: Assessing severity and determining the appropriate site of care
Diagnostic approach to community-acquired pneumonia in adults
Epidemiology and pathogenesis of Legionella infection
Epidemiology, pathogenesis, and microbiology of community-acquired pneumonia in adults
Epidemiology, pathogenesis, microbiology, and diagnosis of hospital-acquired and ventilator-associated pneumonia in adults
Mycoplasma pneumoniae infection in adults
Pneumococcal pneumonia in adults
Pneumonia caused by Chlamydia pneumoniae in adults
Pseudomonas aeruginosa pneumonia
Risk factors and prevention of hospital-acquired and ventilator-associated pneumonia in adults
Sputum cultures for the evaluation of bacterial pneumonia
Treatment of community-acquired pneumonia in adults in the outpatient setting
Treatment of community-acquired pneumonia in adults who require hospitalization
Treatment of hospital-acquired and ventilator-associated pneumonia in adults
Principles of antimicrobial therapy of Pseudomonas aeruginosa infections
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Trimetrexate (Neutrexin) is a significantly more potent inhibitor of DHFR than trimethoprim (Proloprim), 18 so potent that hematopoietic cells must be protected through the coadministration of leucovorin. Although trimetrexate is significantly less toxic than trimethoprim-sulfamethoxazole, it is also less effective. 21 Because it is administered once daily, trimetrexate can be used in outpatients even though it is given intravenously. To mimic the sequential enzyme blockade provided by trimethoprim-sulfamethoxazole, dapsone (100 mg orally) can be added to the regimen.
Acne is often present. Acne conglobata is a particularly severe form of acne that can develop during steroid abuse or even after the drug has been discontinued. Infections are a common side effect of steroid abuse because of needle sharing and unsanitary techniques used when injecting the drugs into the skin. These are similar risks to IV drug abusers with increased potential to acquire blood-borne infections such as hepatitis and HIV/AIDS . Skin abscesses may occur at injection sites and may spread to other organs of the body. Endocarditis or an infection of the heart valves is not uncommon.