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Key steps in the mechanism by which aristolochic acid causes tumours in experimental animals have been identified ( Arlt et al. 2002a ), and are consistent with events occurring in patients with urothelial cancers associated with aristolochic acid nephropathy and Balkan endemic nephropathy. The same DNA adducts identified in humans are also found in experimental animals ( Arlt et al. 2002a , b ) exposed to the natural mixture or the pure major components. A:T→T:A transversions in the TP53 gene in urothelial tumours of aristolochic acid nephropathy and Balkan endemic nephropathy patients were the predominant mutations found in human TP53 knock-in mouse fibroblasts treated with aristolochic acid ( Liu et al., 2004 ; Feldmeyer et al., 2006 ; Arlt et al., 2007 ). Collectively, these data support the strong mechanistic evidence of the carcinogenicity of aristolochic acid – a mixture of aristolochic acids I and II – in humans.

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Balkan pharmaceuticals steroids for sale

balkan pharmaceuticals steroids for sale

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